Seven strangers enrol in an apparently routine drug trial at a pharmaceutical facility, but soon discover an unexpected side effect – they are unable to fall asleep. Concerned for the safety of the patients, the supervising doctor advises the pharmaceutical representatives to stop the trial, although they are more interested in the drug’s potential on the market than the safety of the test subjects.

As the drug’s effects finally begin to subside the participants realise that if they fall asleep they will die. Chaos ensues when the facility is suddenly locked down, and the participants must fight to stay awake for another 24 hours, after already being awake for almost five days straight.